In this study, the effects of different amounts of dietary copper and zinc on serum parameters related to bone metabolism in common carp was determined. Fish weighting 56.56 ± 22.43 g were divided into 5 groups (12 individual/group), were fed at a rate of 3% of body weight for 8 weeks. The Diet contained copper (1 and 3 mg/kg diet) and zinc (7.5 and 15 mg/kg diet) and a control dietary group with no addition of copper and zinc. At the end of the experiment, 8 fish were chosen randomly from each tank and blood samples were taken from the caudal peduncle. Then, serum parameters related to bone metabolism, including calcium, inorganic phosphorus, magnesium, vitamin D3 and alkaline phosphatase were measured. The result showed a significant increase (P<0.05) in serum calcium concentration following Cu2 treatment in comparison with control treatment. Serum phosphorus were reduced significantly in Zn1 and Cu1treatments as compared with control. Although the amounts of serum magnesium and vitamin D3 were elevated in some treatments, the overall changes did not show significant differences (P>0.05). Significant reductions (P<0.05) in the activity of alkaline phosphatase were observed in all treatments compared with controll group. Generally, increase in the levels of the copper and zinc in diet, by changing serum parameters related to bone metabolism can affect bone formation to some extent in common carp.